Next Generation Single-Molecule Biophysics
CHIRLMIN JOO LAB
Using next-generation single-molecule fluorescence techniques, we investigate how small regulatory RNA mediates gene silencing (RNA interference) and anti-viral defense (CRISPR immunity and beyond). We develop single-molecule protein sequencing techniques for advanced proteomics analysis. We organized conferences in 2017, 2019, 2022 .
KEY PUBLICATIONS
Severins, Joo, van Noort, "Exploring molecular biology in sequence space: The road to next-generation single-molecule biophysics", Molecular Cell (2022)
Alfaro et al, "The emerging landscape of single-molecule protein sequencing technologies" Nature Methods (2021)
Filius, Kim, Severins, Joo "High-resolution single-molecule FRET via DNA eXchange" Nano Letters (2021)
Kim, Loeff, Colombo, Jergic, Brouns, Joo "Selective loading and processing of prespacers for precise CRISPR adaptation" Nature (2020) (animation)
Cui, Klein, Hegge, Chandradoss, van der Oost, Depken, Joo "Argonaute bypasses cellular obstacles without hindrance during target search" Nature Communications (2019)
LAB NEWS
Oct 2023 Chirlmin gives a talk in Wageningen University
Sep 2023 Jiyoon starts her internship in TU Delft
Aug 2023 Lab retreat!
Jun 2023 Beray starts his Erasmus+ internship
Jun 2023 Chirlmin gives a talk in VU Amsterdam
Jun 2023 Chirlmin gives a talk in Radboud UMC
Jun 2023 Chirlmin gives a talk in Univ of Munster, Germany
May 2023 Yugyeong from Sang Wook Lee's lab visits us for HFSP collaboration
Apr 2023 Dae Sung Yoon from Korea Univ visits us for ERC-Korea collaboration
Feb 2023 Sung Hyun/Chirlmin's proposal accepted by National Research Foundation of Korea
Feb 2023 Meryem starts her internship
Feb 2023 Sung Hyun gives a talk in BPS
Feb 2023 Chirlmin's interview with Precision Medicine published
Feb 2023 Sinan starts his master project
Feb 2023 Amina starts her master project
Jan 2023 Archana starts her PhD study
Jan 2023 Chirlmin organizes Biophysics Korea-Europe 2023 in Seoul
Jan 2023 Jiyoon starts her internship in Ewha
Jan 2023 Dong Hoon/Sung Hyun's paper accepted in iScience
Jan 2023 Jack starts his faculty position in Utrecht University
See also news in 2011- 2022
Lab protocols (internal use)
Research practicum (Applied Physics)