Next Generation Single-Molecule Biophysics


Using next-generation single-molecule fluorescence techniques, we investigate how small regulatory RNA mediates gene silencing (RNA interference) and anti-viral defense (CRISPR immunity and beyond). We develop single-molecule protein sequencing techniques for advanced proteomics analysis. We organized  conferences in 2017, 2019, 2022 .


Severins, Joo, van Noort, "Exploring molecular biology in sequence space: The road to next-generation single-molecule biophysics", Molecular Cell (2022)

Alfaro et al, "The emerging landscape of single-molecule protein sequencing technologies" Nature Methods (2021)

Filius, Kim, Severins, Joo "High-resolution single-molecule FRET via DNA eXchange" Nano Letters (2021)

Kim, Loeff, Colombo, Jergic, Brouns, Joo "Selective loading and processing of prespacers for precise CRISPR adaptation" Nature (2020) (animation)

Cui, Klein, Hegge, Chandradoss, van der Oost, Depken, Joo "Argonaute bypasses cellular obstacles without hindrance during target search" Nature Communications (2019)


Feb 2024 Carolien gives a talk in Biophysical Society Meeting

Jan 2023 Koushik gives a talk in Single-Molecule Biophysics Les Houches

Dec 2023 Chirlmin gives a talk in CNRS

Dec 2023 Chirlmin gives a talk in imec

Dec 2023 Chirlmin gives a talk in NKI

Nov 2023 Bhagyashree received EMBO Travel Grant

Nov 2023 Our paper has been accepted by Nature Nanotechnology

Oct 2023 Ivo gives a talk in NWO Biophysics

Oct 2023 Chirlmin gives a talk in Wageningen University

Oct 2023 Yorick starts his internship

Sep 2023 Archana and Chirlmin participate Marie-Curie annual workshop in Genoa

Aug 2023 Group retreat!

Aug 2023 Chirlmin gives keynote speech in EKC 2023

Aug 2023 Jieun starts her internship in Ewha

Jul 2023 Chirlmin gives a talk in European Biophysical Society

Jul 2023 Maya starts her summer internship

Jun 2023 Beray starts his Erasmus+ internship

Jun 2023 Sung Hyun receives Outstanding Scientists fellowship from Korea

June 2023 Mike received Kavli Synergy grant

Jun 2023 Chirlmin gives a talk in VU Amsterdam

Jun 2023 Chirlmin gives a talk in Radboud UMC

Jun 2023 Chirlmin gives a talk in Univ of Munster, Germany

May 2023 Yugyeong from Sang Wook Lee's lab visits us for HFSP collaboration

Apr 2023 Dae Sung Yoon from Korea Univ visits us for ERC-Korea collaboration

Feb 2023 Sung Hyun/Chirlmin's proposal accepted by National Research Foundation of Korea

Feb 2023 Meryem starts her internship

Feb 2023 Sung Hyun gives a talk in BPS

Feb 2023 Chirlmin's interview with Precision Medicine published

Feb 2023 Sinan starts his master project

Feb 2023 Amina starts her master project

Jan 2023 Archana starts her PhD study

Jan 2023 Chirlmin organizes Biophysics Korea-Europe 2023 in Seoul

Jan 2023 Jiyoon starts her internship in Ewha

Jan 2023 Dong Hoon/Sung Hyun's paper accepted in iScience

Jan 2023 Jack starts his faculty position in Utrecht University

See also news in 2011- 2022

Lab protocols (internal use)

Research practicum (Applied Physics)

Joo lab in Ewha