Next Generation Single-Molecule Biophysics

CHIRLMIN JOO LAB

Using next-generation single-molecule fluorescence techniques, we investigate how small regulatory RNA mediates gene silencing (RNA interference) and anti-viral defense (CRISPR immunity and beyond). We develop single-molecule protein sequencing techniques for advanced proteomics analysis. We organized conferences in 2017, 2019, 2022 .

KEY PUBLICATIONS

Severins, Joo, van Noort, "Exploring molecular biology in sequence space: The road to next-generation single-molecule biophysics", Molecular Cell (2022)

Alfaro et al, "The emerging landscape of single-molecule protein sequencing technologies" Nature Methods (2021)

Filius, Kim, Severins, Joo "High-resolution single-molecule FRET via DNA eXchange" Nano Letters (2021)

Kim, Loeff, Colombo, Jergic, Brouns, Joo "Selective loading and processing of prespacers for precise CRISPR adaptation" Nature (2020) (animation)

Cui, Klein, Hegge, Chandradoss, van der Oost, Depken, Joo "Argonaute bypasses cellular obstacles without hindrance during target search" Nature Communications (2019)

LAB NEWS

Feb 2023 Sung Hyun/Chirlmin's proposal accepted by National Research Foundation of Korea

Feb 2023 Meryem starts her internship

Feb 2023 Sung Hyun gives a talk in BPS

Feb 2023 Chirlmin's interview with Precision Medicine published

Feb 2023 Sinan starts his master project

Feb 2023 Amina starts her master project

Jan 2023 Archana starts her PhD study

Jan 2023 Chirlmin organizes Biophysics Korea-Europe 2023 in Seoul

Jan 2023 Jiyoon starts her internship in Ewha

Jan 2023 Dong Hoon/Sung Hyun's paper accepted in iScience

Jan 2023 Jack starts his faculty position in Utrecht University