CHIRLMIN JOO LAB
- Using cutting-edge single-molecule fluorescence tools, we investigate how small regulatory RNA mediates gene silencing (RNA interference) and anti-viral defense (CRISPR immunity and beyond). We apply the mechanistic understanding to genome editing.
- We develop single-molecule protein sequencing techniques for advanced proteomics analysis. We organized conferences in 2017 and 2019.
- Kim, Loeff, Colombo, Jergic, Brouns, Joo "Selective loading and processing of prespacers for precise CRISPR adaptation" Nature (2020) (animation)
- Cui, Klein, Hegge, Chandradoss, van der Oost, Depken, Joo "Argonaute bypasses cellular obstacles without hindrance during target search" Nature Communications (2019)
Globyte, Lee, Bae, Kim, Joo "CRISPR/Cas9 searches for a protospacer adjacent motif by lateral diffusion" EMBO Journal (2018) Restrepo, Joo, Dekker "Paving the way to single-molecule protein sequencing" Nature Nanotechnology (2018) van Ginkel, Filius, Szczepaniak, Tulinski, Meyer, Joo "Single-molecule peptide fingerprinting" PNAS (2018)
LAB NEWS
Sep 2021 Alisa joins as a PhD student Apr 2021 Sungchul starts his own group in IBS Center for RNA Research Apr 2021 Melis starts her bachelor project Apr 2021 Luuk's paper accepted in Patterns Apr 2021 Frank starts his master project Mar 2021 FRET.community paper published in eLife Mar 2021 Hamza•Viktorija's paper published in ACS Chemical Biology Mar 2021 Mike•Sung Hyun•Ivo's paper published in Nano Letters Feb 2021 Chirlmin gives a talk in KPS Applied Physics Academy Feb 2021 Carolien's paper accepted in RNA Biology Jan 2021 Chirlmin gives a talk in Dutch Physics Conference Jan 2021 Jack joins as a post-doc
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