Single-Molecule Biophysics


CHIRLMIN JOO LAB

  • Using cutting-edge single-molecule fluorescence tools, we investigate how small regulatory RNA mediates gene silencing (RNA interference) and anti-viral defense (CRISPR immunity and beyond). We apply the mechanistic understanding to genome editing. 
  • We develop single-molecule protein sequencing techniques for advanced proteomics analysis. This research is done in collaboration with Eelkema (TU Delft), Dekker (TU Delft), Maglia (Groningen Univ), and de Ridder (Wageningen UR). See a conference we organized in 2017.

FIVE KEY PUBLICATIONS
  • Globyte, Lee, Bae, Kim, Joo "CRISPR/Cas9 searches for a protospacer adjacent motif by lateral diffusion" EMBO Journal (2018)

  • Restrepo, Joo, Dekker "Paving the way to single-molecule protein sequencing" Nature Nanotechnology (2018)

  • Loeff, Brouns, Joo "Repetitive DNA reeling by the Cascade-Cas3 complex in nucleotide unwinding steps" Molecular Cell (2018)

  • van Ginkel, Filius, Szczepaniak, Tulinski, Meyer, Joo "Single-molecule peptide fingerprinting" PNAS (2018)

  • Fareh, Yeom, Haagsma, Chauhan, Heo, Joo "TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments" Nature Communications, (2016)

 




LAB NEWS
December 2019
Chirlmin gives an invited talk in VIB Tools & Technologies in Ghent, Belgium

October 2019
Sung Hyun joins as a post-doctoral fellow

September 26, 2019
Viktorija defends her PhD thesis

September 2019
Chirlmin organizes the second series of Single-Molecule Protein Sequencing conference in Israel

September 2019
Pim starts a bachelor project

September 2019
Roy starts a master project

September 2019
Carolien joins as a a PhD student

September 2019
Anna defends her bachelor thesis

August 2019
Anne-Wietje defends her bachelor thesis

August 2019
David defends his master thesis

August 2019
Laura•PeggyNathalie's paper accepted by ACS Nano

August 2019
Thijs•MishaStanley's paper accepted by Nature Communications

August 2019
Virgil defends his bachelor thesis

August 2019
Young Yook Kim joins as a visiting scholar

July 2019
Chirlmin gives an invited talk in EKC

July 2019
Chirlmin meets with the president of ERC, Jean-Pierre Bourguignon

July 2019
Sabina defended her master thesis with honours

July 2019
Carolien defends her master thesis

June 2019
Rodrigo finishes his internship

June 2019
Sungchul gives a talk in CRISPR 2019, Quebec City, Cananda

May 2019
Joanna Aizenberg visits for a Kavli Colloquium

May 10, 2019
Laura defends her PhD thesis

May 2019
Shirani defends her bachelor thesis

May 2019
Thijs' paper published in RNA Biology

May 2019
StanleyThijs' paper published in Nucleic Acids Research

April 2019
Chirlmin gives an invited talk in KAIST, Korea

April 2019
Chirlmin gives an invited talk in Keystone (small regulatory RNAs)

April 2019
Adam joins as a post-doctoral fellow (visiting scholar)

March 2019
Interview about the ERC project (mRNA from Nanobiology Association)

March 2019
HFSP Grant awarded for cowork with Sang Wook Lee in Ewha Womans University (news in Delta)

March 2019
Erwin Frey visits as Kavli Chair of 2019

March 2019
Anna starts a bachelor project

February 2019
Chirlmin gives an invited talk in PROSEQO workshop, Barcelona, Spain

February 2019
Virgil starts a bachelor project

February 2019
Luuk awarded Marie-Curie fellowship 

February 2019
Rodrigo starts master internship

February 2019
Viktorija•Hwan's paper highlighted in EMBO Journal

February 2019
Laura's paper published in ACS Nano

January 2019
Viktorija's paper published in Methods in Enzymology

January 2019
Luuk awarded Rubicon fellowship (Delta interview)

January 2019
Ronald van Rij from Radboud UMC visits our group

January 2019
Chirlmin gives a talk in Seoul National Univ, Korea

Subpages (1): News archive