Single-Molecule Biophysics


  • Using cutting-edge single-molecule fluorescence tools, we investigate how small RNA mediates gene silencing (RNA interference) and anti-viral defense (CRISPR immunity and DNA interference). We apply the mechanistic understanding to genome editing. 
  • We develop single-molecule protein sequencing techniques for advanced proteomics analysis. This research is done in partnership within TU Delft (Dekker, Eelkema, Meyer), Groningen Univ (Maglia), Wageningen UR (de Ridder)

  • Loeff, Brouns, Joo "Repetitive DNA reeling by the Cascade-Cas3 complex in nucleotide unwinding steps" Molecular Cell (2018)

  • van Ginkel, Filius, Szczepaniak, Tulinski, Meyer, Joo "Single-molecule peptide fingerprinting" PNAS (2018)

  • Restrepo-Pérez, John, Aksimentiev, Joo, Dekker, "SDS-assisted protein transport through solid-state nanoporesNanoscale (2017)

  • Fareh, Yeom, Haagsma, Chauhan, Heo, Joo "TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments" Nature Communications, (2016)

  • Chandradoss, Schirle, Szczepaniak, MacRae, Joo "A dynamic search process underlies microRNA targeting" Cell (2015)


April 2019
Chirlmin gives invited talk in Keystone symposium (small regulatory RNAs)

September 2018
Valerie joins for her PhD study

September 2018
Chirlmin becomes co-director of Kavli Institute of Nanoscience in Delft

July 2018
Mohamed starts scientist position in Peter MacCallum Centre in Australia

June 2018
Chirlmin gives invited talk in Jacques Monod conference in France

May 2018
Luuk gives plenary talk in RNA Society Meeting

April 2018
Luuk's paper highlighted by TU Delft (molecular fishing rod and shredder)

April 2018
Luuk's paper published in Molecular Cell

April 2018
Rochelle starts bachelor project

April 2018
Kazufumi Mochizuki from CNRS visits our group

April 2018
Hagan Bayley's group from Oxford visits our group

April 14, 2018
Group BBQ party with chefs Filius and Loeff!

April 2018
Ferdy starts bachelor project

April 2018
Viktorija•Sung Hyun's paper published in Annual Review of Biophysics

March 2018
Jetty•Mike•Malwina•Pawel's paper published in PNAS

February 2018
Mohamed gives talk in SignaLife conference in Nice, France

February 2018
Peggy joins the sequencing team

January 2018
Hamza Balci awarded Marie-Curie Fellowship

January 2018
Jetty gives a talk in Physics@Veldhoven

January 2018
Antoine starts Honours project

January 2018
Isabell starts master project

January 2018
Mohamed•Jasper•Iasonas•Anna's paper published in Nucleic Acids Research

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