Single-Molecule Biophysics


CHIRLMIN JOO LAB

  • Using cutting-edge single-molecule fluorescence tools, we investigate how small RNA mediates gene silencing (RNA interference) and anti-viral defense (CRISPR immunity and DNA interference). We apply the mechanistic understanding to genome editing. 
  • We develop single-molecule protein sequencing techniques for advanced proteomics analysis. This research is done in partnership within TU Delft (Dekker, Eelkema, Meyer), Groningen Univ (Maglia), Wageningen UR (de Ridder). See a conference we organized in 2017.

FIVE KEY PUBLICATIONS
  • Restrepo, Joo, Dekker "Paving the way to single-molecule protein sequencing" Nature Nanotechnology (2018)

  • Loeff, Brouns, Joo "Repetitive DNA reeling by the Cascade-Cas3 complex in nucleotide unwinding steps" Molecular Cell (2018)

  • van Ginkel, Filius, Szczepaniak, Tulinski, Meyer, Joo "Single-molecule peptide fingerprinting" PNAS (2018)

  • Fareh, Yeom, Haagsma, Chauhan, Heo, Joo "TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments" Nature Communications, (2016)

  • Chandradoss, Schirle, Szczepaniak, MacRae, Joo "A dynamic search process underlies microRNA targeting" Cell (2015)

 




LAB NEWS
April 2019
Chirlmin gives invited talk in Keystone symposium (small regulatory RNAs)

December 2018
Thijs gives talk in NWO CHAIN (Chemistry)

October 2018
Marjolein starts bachelor project

October 2018
Mike gives talk in NWO Biophysics

September 2018
Ivo•Malwina's paper published in Biophysical Journal

September 2018
Laura's paper published in Nature Nanotechnology

September 2018
Cecilia joins as a technician

September 2018
Adi joins as a guest researcher

September 2018
Valerie joins the RNA team

September 2018
Chirlmin becomes Director of Kavli Institute of Nanoscience in Delft (interview)

August 2018
Chun finished his master study with cum laude

August 2018
A startup company Bluemics launched. We develop a single-molecule protein sequencer.

July 2018
Chirlmin gives talks in MIT, Harvard, and Broad Institute.

July 2018
Shirani starts bachelor project

July 2018
Mohamed starts scientist position in Peter MacCallum Centre in Australia

July 2018
Ferdy defends bachelor thesis

July 2018
Hamza joins as a visiting scholar

May 2018
Luuk gives plenary talk in RNA Society Meeting

April 2018
Luuk's paper highlighted by TU Delft (molecular fishing rod and shredder)

April 2018
Luuk's paper published in Molecular Cell

April 2018
Rochelle starts bachelor project

April 2018
Kazufumi Mochizuki from CNRS visits our group

April 2018
Hagan Bayley's group from Oxford visits our group

April 14, 2018
Group BBQ party with chefs Filius and Loeff!

April 2018
Ferdy starts bachelor project

April 2018
Viktorija•Sung Hyun's paper published in Annual Review of Biophysics

March 2018
Jetty•Mike•Malwina•Pawel's paper published in PNAS

February 2018
Mohamed gives talk in SignaLife conference in Nice, France

February 2018
Peggy joins the sequencing team

January 2018
Hamza Balci awarded Marie-Curie Fellowship

January 2018
Jetty gives a talk in Physics@Veldhoven

January 2018
Antoine starts Honours project

January 2018
Isabell starts master project

January 2018
Mohamed•Jasper•Iasonas•Anna's paper published in Nucleic Acids Research

Subpages (1): News archive