Single-Molecule Biophysics


  • Using cutting-edge single-molecule fluorescence tools, we investigate how small RNA mediates gene silencing (RNA interference) and anti-viral defense (CRISPR immunity and DNA interference). We apply the mechanistic understanding to genome editing. 
  • We develop single-molecule protein sequencing techniques for advanced proteomics analysis. This research is done in partnership within TU Delft (Dekker, Eelkema, Meyer) and with Groningen Univ (Maglia) & Wageningen UR (de Ridder). See a conference we organized in 2017.

  • Globyte, Lee, Bae, Kim, Joo "CRISPR/Cas9 searches for a protospacer adjacent motif by lateral diffusion" EMBO Journal (2018)

  • Restrepo, Joo, Dekker "Paving the way to single-molecule protein sequencing" Nature Nanotechnology (2018)

  • Loeff, Brouns, Joo "Repetitive DNA reeling by the Cascade-Cas3 complex in nucleotide unwinding steps" Molecular Cell (2018)

  • van Ginkel, Filius, Szczepaniak, Tulinski, Meyer, Joo "Single-molecule peptide fingerprinting" PNAS (2018)

  • Fareh, Yeom, Haagsma, Chauhan, Heo, Joo "TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments" Nature Communications, (2016)


December 2019
Chirlmin gives invited talk in VIB Tools & Technologies in Gent, Belgium

September 2019
Chirlmin organizes the second series of Single-Molecule Protein Sequencing conference in Israel

May 10, 2019
Laura defends PhD thesis

April 2019
Chirlmin gives invited talk in KAIST, Korea

April 2019
Chirlmin gives invited talk in Keystone symposium (small regulatory RNAs)

March 2019
Erwin Frey visits as Kavli Chair of 2019

March 2019
Adam joins as a visiting scholar

February 2019
Chirlmin gives invited talk in PROSEQO workshop, Barcelona, Spain

February 2019
Virgil starts bachelor project

February 2019
Rodrigo starts master internship

January 2019
Ronald van Rij from Radboud UMC visits our group

January 2019
Luuk awarded Rubicon fellowship (Delta interview)

January 2019
Chirlmin gives a talk in Seoul National Univ, Korea

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