Single-Molecule Biology: Exploring Beyond the Genome


CHIRLMIN JOO LAB

  • Using cutting-edge single-molecule fluorescence tools, we investigate how non-coding RNAs trigger anti-viral defence via CRISPR immunity and regulate transcriptome via RNA interference. Our mechanistic understanding is applied to genome editing and gene regulation. 
  • We are developing single-molecule protein sequencing techniques for advanced proteomic analysis. PhD and postdoc positions are available.
Check Chirlmin's ambition in self-interviews (English) (Korean).

RECENT KEY PUBLICATIONS

M. Fareh, K. H. Yeom, A. C. Haagsma, S. Chauhan, I. Heo, & C. Joo (2016) "TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environmentsNature Communications (open access)

M. Klein, S. D. Chandradoss, M. Depken, C. Joo "Why Argonaute is needed to make microRNA target search fast and reliable" Seminars in Cell & Developmetal Biology (in press

Y. Yao, M. Docter, J. van Ginkel, D. de Ridder, & C. Joo (2015) "Single-molecule protein sequencing through fingerprinting: computational assessment" Physical Biology (open access)

S. D. Chandradoss, N. T. Schirle, M. Szczepaniak, I. J. MacRae, & C. Joo, (2015) “A Dynamic Search Process Underlies MicroRNA Targeting” Cell (PDF)

T. R. Blosser, L. Loeff, E. R. Westra, M. Vlot, T. Kunne, M. Sobota, C. Dekker, S. J. J. Brouns, & C. Joo (2015) "Two Distinct DNA Binding Modes Guide Dual Roles of a CRISPR-Cas Protein Complex" Molecular Cell (PDF)

OPENINGS
 




LAB NEWS
July 2017
Laura gives talk in a nanopore conference in Bremen, Germany

May 2017
Chirlmin delivers keynote speech in Labex SIGNALIFE, Nice, France

May 2017
Ilja joins as a technician

April 2017 
Luuk defends his PhD

April 2017 
Nicola joins for master project

March 2017
Mike•Iasonas•Thijs give talks in NanoFront Retreat

February 2017 
Laura gives talk in Biophysical Society Meeting in New Orleans, US

February 2017 
Thijs gives talk in Biophysical Society Meeting in New Orleans, US

February 2017
Chirlmin gives talk in Biophysical 
Society Meeting in New Orleans, US

February 2017
Justine joins for bachelor project

February 2017
Erwin joins for bachelor project

February 2017
Lois joins for bachelor project

February 2017
Dieuwertje finishes bachelor project

January 2017
Malwina starts new position in Portland

January 2017
Mohamed gives talk in Keystone Symposia (noncoding RNAs), Canada

January 2017
Natalie finishes bachelor project

January 2017
MalwinaStanley's paper accepted in Molecular Cell

January 2017
Vrije FOM programme starts

Subpages (1): News archive