CHIRLMIN JOO LAB
- Using cutting-edge single-molecule fluorescence tools, we investigate how small RNA mediates gene silencing (RNA interference) and anti-viral defense (CRISPR immunity and DNA interference). We apply the mechanistic understanding to genome editing.
- We develop single-molecule protein sequencing techniques for advanced proteomics analysis. This research is done in partnership within TU Delft (Dekker, Eelkema, Meyer) and with Groningen Univ (Maglia) & Wageningen UR (de Ridder). See a conference we organized in 2017.
Globyte, Lee, Bae, Kim, Joo "CRISPR/Cas9 searches for a protospacer adjacent motif by lateral diffusion" EMBO Journal (2018) Restrepo, Joo, Dekker "Paving the way to single-molecule protein sequencing" Nature Nanotechnology (2018) Loeff, Brouns, Joo "Repetitive DNA reeling by the Cascade-Cas3 complex in nucleotide unwinding steps" Molecular Cell (2018) -
van Ginkel, Filius, Szczepaniak, Tulinski, Meyer, Joo "Single-molecule peptide fingerprinting" PNAS (2018)
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Fareh, Yeom, Haagsma, Chauhan, Heo, Joo "TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments" Nature Communications, (2016)
| | LAB NEWS
December 2019 Chirlmin gives invited talk in VIB Tools & Technologies in Gent, Belgium
September 2019 Chirlmin organizes the second series of Single-Molecule Protein Sequencing conference in Israel
May 10, 2019 Laura defends PhD thesis
April 2019 Chirlmin gives invited talk in KAIST, Korea
April 2019 Chirlmin gives invited talk in Keystone symposium (small regulatory RNAs)
March 2019 Erwin Frey visits as Kavli Chair of 2019
March 2019 Adam joins as a visiting scholar
February 2019 Chirlmin gives invited talk in PROSEQO workshop, Barcelona, Spain
February 2019 Virgil starts bachelor project
February 2019 Rodrigo starts master internship
January 2019 Ronald van Rij from Radboud UMC visits our group
January 2019 Chirlmin gives a talk in Seoul National Univ, Korea |
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