Single-Molecule Biophysics


CHIRLMIN JOO LAB

  • Using cutting-edge single-molecule fluorescence tools, we investigate how small RNA and DNA mediate gene silencing (RNA interference) and anti-viral defense (CRISPR immunity and DNA interference). We apply the mechanistic understanding to genome editing. 
  • We develop single-molecule protein sequencing techniques for advanced proteomic analysis. Postdoc positions are available.


FIVE KEY PUBLICATIONS
  • Swarts, Szczepaniak, Sheng, Chandradoss, Zhu, Timmers, Zhang, Lou, Wang, Joo, & van der Oost, "Autonomous generation and loading of DNA guides by bacterial Argonaute" Molecular Cell (2017)
  • Fareh, Yeom, Haagsma, Chauhan, Heo, & Joo "TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments" Nature Communications (2016)
  • Yao, Docter, van Ginkel, de Ridder, & Joo "Single-molecule protein sequencing through fingerprinting: computational assessment" Physical Biology (2015)
  • Chandradoss, Schirle, Szczepaniak, MacRae, & Joo “A dynamic search process underlies microRNA targeting” Cell (2015)
  • Blosser, Loeff, Westra, Vlot, Kunne, Sobota, Dekker, Brouns, & Joo "Two Distinct DNA Binding Modes Guide Dual Roles of a CRISPR-Cas Protein Complex" Molecular Cell (2015)
 




LAB NEWS
December 2017
We host the first international Single-Molecule Protein Sequencing workshop (registration)

November 2017
Sabina starts master project

October 6, 2017 
Luuk defends his PhD

October 2017
Viktorija gives talk in NWO Biophysics, Veldhoven

October 2017
Chirlmin delivers plenary talk in NWO Biophysics, Veldhoven

September 2017
Ivo joins for PhD study

September 2017
Berkalp finishes master project

September 2017
Sonja joins the sequencing team

August 2017
Esmee finishes master project

July 2017
Laura gives talk in nanopore conference in Bremen, Germany 

July 2017
Stanley starts new position in Oxford NanoImaging

July 2017
Erwin finishes bachelor project

July 2017
Lois finishes bachelor project

July 2017
Justine finishes bachelor project

July 2017
Laura's paper accepted in Nanoscale

June 2017
NanoFront grant awarded

June 2017
Chirlmin gives talk in Max Planck Institute in Goettingen

June 2017
Chirlmin gives talk in Univ of Utah, US

June 2017
Chirlmin gives talk in CRISPR conference in Montana, US 

June 2017
Jetty awarded Marina van Damme scholarship

May 2017
Chirlmin gives talk in Hubrecht Institute

May 2017
Chirlmin gives talk in Wageningen UR

May 2017
Chirlmin delivers keynote speech in Labex SIGNALIFE, Nice, France

May 2017
Ilja joins as technician

April 2017 
Nicola joins for master project

March 2017
Mike awarded Best Poster Presentation in BioDay

March 2017
Malwina•Stanley's paper published in Molecular Cell

February 2017
Luuk awarded Best Oral Presentation in Kyoto University

February 2017
Ivo joins the sequencing team

February 2017 
Laura gives talk in Biophysical Society Meeting in New Orleans, US

February 2017 
Thijs gives talk in Biophysical Society Meeting in New Orleans, US

February 2017
Chirlmin gives talk in Biophysical 
Society Meeting in New Orleans, US

February 2017
Justine joins for bachelor project

February 2017
Erwin joins for bachelor project

February 2017
Lois joins for bachelor project

February 2017
Mohamed gives talk in Keystone Symposia (noncoding RNAs), Canada

February 2017
Dieuwertje finishes bachelor project

January 2017
Sungchul awarded Marie-Curie fellowship

January 2017
Malwina starts new position in DiabetOmics

January 2017
Natalie finishes bachelor project

January 2017
Vrije FOM programme starts

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