Single-Molecule Biophysics


  • Using cutting-edge single-molecule fluorescence tools, we investigate how small regulatory RNA mediates gene silencing (RNA interference) and anti-viral defense (CRISPR immunity and beyond). We apply the mechanistic understanding to genome editing. 
  • We develop single-molecule protein sequencing techniques for advanced proteomics analysis. We organized  conferences in 2017 and 2019.

  • Kim, Loeff, Colombo, Jergic, Brouns, Joo "Selective loading and processing of prespacers for precise CRISPR adaptation" Nature (2020)
  • Cui, Klein, Hegge, Chandradoss, van der Oost, Depken, Joo "Argonaute bypasses cellular obstacles without hindrance during target search" Nature Communications (2019)
  • Globyte, Lee, Bae, Kim, Joo "CRISPR/Cas9 searches for a protospacer adjacent motif by lateral diffusion" EMBO Journal (2018)

  • Restrepo, Joo, Dekker "Paving the way to single-molecule protein sequencing" Nature Nanotechnology (2018)

  • van Ginkel, Filius, Szczepaniak, Tulinski, Meyer, Joo "Single-molecule peptide fingerprinting" PNAS (2018)


December 2020
Jack joins as a post-doc

November 2020
Mike gives a talk in Single-molecule Sensors and NanoSystems

October 2020
Carolien gives a talk in NWO Biophysics

September 2020
Dong-Hoon joins as a post-doc

September 2020
Raman starts a master project

September 2020
Bhagyashree joins as a post-doc

August 2020
Tygo defends his bachelor thesis

July 2020
Thijs' paper published in Nature Structural & Molecular Biology

July 2020
Delft Health Initiative grant awarded

July 2020
Pim defends his master thesis

July 2020
Sungchul's work highlighted in European Commission

June 2020
Chirlmin receives Hansung Science Award (news)

June 2020
Roy defends his master thesis

May 28, 2020
Chirlmin gives a Nature Webcast

April 2020
Sungchul's paper accepted by Nature Communications

April 2020
Mike's paper published in Angewandte Chemie

March 2020
Mike•Thijs•Margreet's paper published in Nano Letters

February 2020
Our Cas1-2 work highlighted by TU Delft (News)

February 2020
Sungchul•Luuk•Sabina's paper published in Nature

February 2020
Tygo starts a bachelor project

February 2020
Taekjip (TJ) Ha gives a Kavli Colloquium talk

January 2020
Woo-Chan joins as a visiting scholar

January 2020
Laura starts her position in Vintura

Subpages (1): News archive