KEY RESEARCH ARTICLES                                                                                                                      
* corresponding authorship
See also papers we published as contributing authors                                                                     
§ equal contribution

L. Loeff, S. J. J. Brouns*, C. Joo* (under revision)

I. Severins, M. Szczepaniak, C. Joo* (submitted)

M. Fareh, I. Katechis, J. van Lopik, A. W. Bronkhorst, A. C. van Eijkeren-Haagsma, R. P. van Rij*, C. Joo* (submitted)

L. Restrepo-Pérez, C. Joo*, C. Dekker* (under revision)

J. van Ginkel, M. Filius, M. Szczepaniak , P. Tulinski , A. S. Meyer*, C. Joo* (under revision)

S. M. Klum
, S. D. Chandradoss
, N. T. Schirle, C. Joo*, I. J. MacRae* "Helix-7 in Argonaute2 shapes the microRNA seed region for rapid target recognition" EMBO Journal (open access)

L. Restrepo-Pérez
, S. John
, A. Aksimentiev*, C. Joo*, C. Dekker*, "SDS-assisted protein transport through solid-state nanopores" Nanoscale (2017) (published online)

SDS-coated Titin dimer translocation

D. C. Swarts
, M. Szczepaniak
, G. Sheng
, S. D. Chandradoss, Y. Zhu, E. M. Timmers, Y. Zhang, J. Lou, Y. Wang*,
C. Joo*, & J. van der Oost* "Autonomous generation and loading of DNA guides by bacterial Argonaute
Molecular Cell (2017) (interactive, PDF)
Highlight in Molecular Cell

M. Fareh, K. H. Yeom, A. C. Haagsma, S. Chauhan, I. Heo, & C. Joo* "TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environmentsNature Communications 7:13694 doi:10.1038/ncomms13694 (2016) (open access)

N. T. Schirle, J. Sheu-Gruttadauria, S. D. ChandradossC. Joo*, & I. J. MacRae* “Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets.” eLife 4:e07646 (2015) (open access)

Y. Yao, M. Docter, J. van Ginkel, D. de Ridder*, & C. Joo* "Single-molecule protein sequencing through fingerprinting: computational assessment" Physical Biology, 12(5):055003 (2015) (open access)

S. D. Chandradoss, N. T. Schirle
M. Szczepaniak
, I. J. MacRae*, & C. Joo* “A dynamic search process underlies microRNA targeting” Cell, 162(1):96-107 (2015) (interactivePDF) (PMC free text)
Highlight in Molecular Cell

B. Kim§, M. Ha§L. Loeff§, H. Chang, D. K. Simanshu, S. Li, M. Fareh, D. J. Patel, C. Joo*, & V. N. Kim* "TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms" EMBO Journal, 34(13):1801-15 (2015) (open access)

T. R. Blosser§L. Loeff§, E. R. Westra, M. Vlot, T. Kunne, M. Sobota, C. Dekker, S. J. J. Brouns*, & C. Joo* "Two distinct DNA binding modes guide dual roles of a CRISPR-Cas protein complex" Molecular Cell, 58(1):50-60 (2015) (interactivePDF) (PMC free text)

K. H. Yeom, I. Heo, J. Lee, S. Hohng, V. N. Kim*, & C. Joo*, "Single-molecule approach to immunoprecipitated protein complexes: insights into miRNA uridylation" EMBO Reports, 12, 690-696 (2011) (PDFsupplements) (PMC free text)


M. Klein
S. D. Chandradoss
, M. Depken*, C. Joo* "Why Argonaute is needed to make microRNA target search fast and reliable" Seminars in Cell & Developmental Biology (2017) (open access

C. Joo*, M. Fareh, V. N. Kim "Bringing single-molecule spectroscopy to macromolecular protein complexes" Trends in Biochemical Sciences, 38(1):30-37 (2013) (interactivePDF) (PMC free text)


M. Fareh, L. Loeff, M. Szczepaniak, A. C. Haagsma, K. H. Yeom, C. Joo* "Single-molecule pull-down for investigating protein—nucleic acid interactions" Methods, 105:99-108 (2016) (PDF) (PMC free text)

S. D. Chandradoss, A. C. Haagsma, Y. K. Lee, J. H. Hwang, J. M. Nam, & C. Joo* "Surface passivation for single-molecule protein studies" Journal of Visualized Experiments, (86), e50549, doi:10.3791/50549 (2014) (open access)


C. Joo, C. Dekker, H. G. T. M. van Ginkel, A. S. Meyer, Single-molecule protein sequencing, WO2014014347

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