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Chirlmin Joo



Chirlmin Joo studied physics at Seoul National University in Korea. He obtained his PhD in physics under the supervision of Taekjip Ha at the University of Illinois at Urbana-Champaign, USA. He studies a DNA repair process using single-molecule fluorescence techniques. During his PhD study, he advanced single-molecule techniques by innovating new tools including multi-color single-molecule FRET. As a post-doctoral fellow in Narry Kim’s lab at Seoul National University, he discovered novel proteins in microRNA biogenesis. In 2011, he started his faculty position in Department of Bionanoscience at Delft University of Technology in the Netherlands. He developed the first single-molecule pull-down technique (the reconstitution of functional protein complexes at the single-molecule level). He applied the single-molecule multi-color FRET and the single-molecule pull-down methods to mechanistic studies on the target search process of microRNA and CRISPR/Cas9 and the functional studies of protein complexes in microRNA biogenesis and CRISPR memory formation.

In 2017, Chirlmin Joo took leadership of developing new techniques of “single-molecule protein sequencing” in a Dutch national science program (NWO-FOM Vrije Programme). His team aims at developing high-resolution single-molecule techniques that can, for the first time, determine protein sequences at the single-molecule level. Using single-molecule fluorescence and nanopores, his team is exploring the biophysics of protein translocation and will utilize it to develop a novel technology to determine the sequence of proteins. By analyzing proteins molecule by molecule, his team will be able to read the entire proteome, despite its complex nature and the wide dynamic range of abundances of cellular proteins. The new technology will be the first to create the opportunity for single-cell proteomics and real-time screening for on-site medical diagnostics.

In 2018, Chirlmin Joo was appointed Director of Kavli Institute of Nanoscience Delft. He is the co-founder of a startup company, Bluemics.


GROUP LEADER
Curriculum Vitae (CV 2018)
Interviews (Kavli, Bio Korea, Delta)
Personal Interests
Publications
h-index: 21 (as of 2018)
Google scholar
ResearcherID: B-9294-2008
Director (2018-present)
Associate Professor (2016-present)
Department of BioNanoScience, Delft University of Technology (TU Delft)
Assistant Professor (2011-2015)
Department of BioNanoScience, Delft University of Technology (TU Delft)
Research Professor (2009-2010)

EDUCATION
Ph. D. (2007)
PhysicsUniversity of Illinois at Urbana-Champaign
B. S. (2002) summa cum laude
PhysicsSeoul National University

PROFESSIONAL ACTIVITIES
Reviewer of Nature journals, Cell Press journals, Science, PNAS, Nucleic Acids Research, ACS journals, Angewandte Chemie, PLoS, ...
Director of Kavli Institute of NanoScience in Delft
Editorial Board of Scientific Reports
Management team of BioNanoScience (2015-2018)
Organizer of Quo Vadis seminar series in BioNanoScience (since 2012)
Advisory committee member of Kavli Institute of Nanoscience in Delft (2013-2015) 
NWO-CW studygroup (2015-2016)
Committee member of MasterStudyTour (2012-2014)
Head of Korean Scientists & Engineers Association in the Netherlands (2014-2015)
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Chirlmin Joo,
22 Dec 2018, 00:41
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