Student Projects

We are looking for motivated master students with background of physics, biology, or chemistry. Several exciting, independent projects are available. If you are interested in doing a master project abroad, we can arrange an internship project in a biology/biophysics lab in Korea.

High throughput single-molecule detection
We have a project that will make a breakthrough (observation of millions of molecules at a time). You will set up a new microscope with a new generation camera. You will also couple DNA deep sequencing technique with single-molecule fluorescence. You should have background in electronic instrumentation and programming.

Berkalp Doğaner
Ivo Severins (publications)

Single-molecule protein sequencing
You will develop a single‐molecule protein sequencer using single-molecule fluorescence and nanopores. Your participation will make the first single-molecule protein sequencer realized in the world.

Isabell Trinh
Chun Heung Wong
Nicola Bellotto

Lois van der Drift
Nathalie Worp (publications)
Louis-Marie Chauveau (publications)
Mike Filius (publications)
Yao Yao (publications)
Mees de Graaf

CRISPR (genome editing)
You will investigate how CRISRP targets viral genome. You will study this mechanism using single-molecule fluorescence. You will be given an opportunity to build an advanced multi-color single-molecule microscope. 
Your study will make a breakthrough for advancing genome editing tools. 

Sabina Colombo
Justine Tang
Erwin Erdem
Tim Allertz
Nick de Lange

RNA/DNA interference (gene silencing)
You will investigate how microRNA/microDNA is generated and finds its target RNA/DNA. You will study this mechanism using single-molecule fluorescence and computer simulation. The outcome of your study will be used for improving the efficiency of RNA/DNA interference for therapeutics.

Dieuwertje Drexhage (publications)
Jasper van Lopik (publications)
Melissa Kerver
Abidemi Junaid
Maxime den Ridder
Sweeny Chauhan (publications)

Early embryo mechanics
A project for a student in physics or biology. In collaboration with Timon Idema's group, you will use a lab-built high-speed confocal microscope to image live cells and invest their mechanical properties. Contact Timon Idema.

Esmée Adegeest
Soufian Lemkaddem (publications)

Ilias Zarguit 

DNA pH sensor
Jeroen de Vries
Giacomo Casarosa

It was 
Abidemi Junaid, a master student

"I learned a lot about using interdisciplinary approaches. I had a taste of what it means to work as a PhD student, which involves hard work, creativity and enjoyment. My lab mates were social, open and happy about their work. These things made my internship fun. The project that I did was cool. (I often brag about it when people ask for my work experience). It was the first project that I had the opportunity to collaborate with another department. This was useful for me because my PhD project is a collaboration of three parties."

Accomplished my goals

Nick de Lange, a bachelor student

"This was a great opportunity to finally use my prior knowledge for an interesting project. I could also get hands-on experience. I found the lab was a great place to accomplish my goals, and the lab members were very helpful."

Felt excited and proud to work
Yao Yao, a master student

"My bioinformatics project was a part of a much bigger and ambitious one that would save the world. I found the lab lively and members friendly and rigorous. I was glad that I could meet my supervisors at least once per week. I developed an interest in wet lab work during my MEP and was given an opportunity to work in the wet lab after my MEP."

A multidisciplinary field
Ivo Severins, a master student

"My supervisor explained everything clearly and answered my questions patiently. There was always room for discussion, and I could put forward my own ideas and suggestions. There is a nice, friendly and open atmosphere in the lab, and people are always ready to help. This project was a great opportunity to work in a multidisciplinary field, combining both physical and biological research."

Leading a project on my own
Maxime den Ridder, a bachelor student

"I had a chance to improve my wet lab skills. I learned how to overexpress, label and purify proteins. It was also interesting to learn about single-molecule studies and to see how useful it is for tracking dynamic cellular processes. I was asked to take responsibility for my project (planning experiments and analyzing results) while I was always able to discuss with my supervisors. Everybody in the lab was also always willing to answer any of my questions."

Learned to have fun doing science
Sweeny Chauhan, a bachelor student

"It is till date my best experience in a lab. I was able to learn a lot, not just regarding lab techniques but also for a scientific career. From the starting I was allowed to plan and execute my projects independently. I had great supervisors who enjoyed teaching and always helped me out with questions and doubts. I was able to improve my skills, ranging from wet lab techniques to presentations and critical questioning. Overall it was a memorable experience. I did not only gain a lot of experience and knowledge but also learned to have fun doing science. I would choose any opportunity to again work here."

Opportunity to develop yourself!
Soufian Lemkaddem, a master student

"It was a great opportunity to develop my experimental skills. I got a lot of responsibility, but at the same time I was supervised at the right moments. The lab members stimulated me in a polite and positive way during my research, and that gave me positive energy to excellence in my work.  We also had fun inside and outside the lab.  The hard working and good supervision resulted in a great grade and a completely new setup--ready to be used for promising research by new students!"